Day 7: Aronia effects on tumor cells

Cytotoxic and DNA-Damaging Effects of Aronia melanocarpa, Cornus mas, and Chaenomeles superba Leaf Extracts on the Human Colon Adenocarcinoma Cell Line Caco-2

by Magdalena Efenberger-Szmechtyk, Adriana Nowak, and Agnieszka Nowak

Antioxidants 2020, 9(11), 1030; https://doi.org/10.3390/antiox9111030

1. human epithelial colorectal adenocarcinoma cell line (Caco-2) cells were treated with aronia leaf extracts

2. an assay known as a Comet Assay was used to assess the amount of DNA damage

3. CONTROL cells exhibit no measurable damage, but cells treated with the 3 different types of leaf extracts show marked DNA damage (bigger “comet” tails)

4. The conclusion is that these extracts can be used to counteract the survival and introduce CYTOTOXICITY to tumor (cancerous) cells